GenoType^® MTBDRsl - Your Important Assistance for Detetion of XDR-TB

Identification of the M. tuberculosis complex and its resistance to fluoroquinolones (e.g. ofloxacin and moxifloxacin) and/or aminoglycosides/cyclic peptides (injectable antibiotics as capreomycin, viomycin/kanamycin, amikacin) and/or ethambutol

If TB is diagnosed properly, it is curable and millions of people all over the world have been healed from the illness. But if the anti-TB drugs are misused or mismanaged, multidrug-resistant TB (MDR-TB) and even extensively drug-resistant TB (XDR-TB) can develop. The consequence of which is that MDR-TB and XDR-TB does not respond to standard treatments.
MDR-TB takes longer to treat with the more expensive second line drugs that have more side-effects. Furthermore drug-resistant TB is more likely to cause death.
XDR-TB describes TB, caused by strains of M. tuberculosis that are not only resistant to the first line drugs rifampicin and isoniazid, two of the most important drugs used to treat TB but also resistant to any of the fluoroquinolones and at least one of the injectable anti-TB drugs used when “first-line” treatment has failed. Therefore treatment options are seriously limited.
To prevent and control the spread of XDR-TB it is essential to have access to laboratory facilities with rapid tests for TB and drug susceptibility testing (DST) to provide proper diagnosis and treatment to all TB patients.

Our GenoType^® MTBDRsl gives you the possibility to diagnose patients with MDR-TB to receive information on further antibiotic resistances, to test patient after therapy failure and relapse as well as to diagnose patients from countries with high usage of the respective drugs. 

The identification of resistance to fluoroquinolones is enabled by the detection of the most significant mutations of the gyrA gene (coding for DNA gyrase). For the detection of resistance to aminoglycosides/cyclic peptides, the 16S rRNA gene (rrs) and for detection of resistance to ethambutol the embB gene (which, together with the genes embA and embC, codes for arabinosyl transferase) are examined.

Your benefits with GenoType^® MTBDRsl

• Detection of XDR-TB in patients previously diagnosed with an MDR-TB by testing with the GenoType^® MTBDRplus.
• Confirmation of DST results.

At a glance
Molecular genetic assay for identification of resistance to fluoroquinolones, aminoglycosides/cyclic peptides and ethambutol of Mycobacterium tuberculosis complex

Starting material:
decontaminated pulmonary smear-positive specimens and/or liquid/solid culture samples

DNA Isolation:
quick protocol (for further informaton please refer to the manual)

Order number:
12 tests  No. 317
96 tests  No. 31796