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FluoroType® HSV

Your test system for direct detection of HSV-1 and HSV-2 from patient samples

Herpes simplex viruses (HSV) are spread worldwide and to date, genital herpes is one of the most prevalent sexually transmitted diseases in industrialized countries. The prevalence accounts for approximately 70-95% for HSV-1 and 10-20% for HSV-2, but can be considerably higher for risk groups. The primary infection occurs without symptoms in more than 90% of the cases . However, reactivation of the virus in nerve ganglia leads to a clinically manifest HSV recurrence or asymptomatic shedding. Because of the diversity and complexity of disease patterns, clinical diagnosis is difficult. Besides typical blisters around the face, mouth, and genitals, both virus types can also cause severe infections of the central nervous system, such as aseptic meningitis or herpes simplex encephalitis in neonates or immunesuppressed patients. Since a specific therapy is available for most disease patterns, severe progressive forms and transmission rates can be effectively prevented by an early and reliable diagnostics.

assay principle of FluoroType®  HSV

FluoroType® HSV enables fast and reliable molecular diagnostics of HSV based on innovative technology. HSV DNA is extracted from clinical swab specimens or liquor samples using GenoXtract® followed by amplification, detection and analysis in the FluoroCycler®. The results are available within 3 hours and are differentiated between HSV-1 and HSV-2. In comparison to culture or serology, elaborate and time-consuming steps are dispensed. Since the detection is carried out independently from the presence of specific antibodies, FluoroType® HSV is also applicable for children and neonates. This enables the immediate initiation of an antiviral therapy as well as adequate prevention measures.

Your benefits of using FluoroType® HSV

  • Fast results: Test procedure delivers for rapid results within 3 hours and thereby enables the initiation of immediate therapy measures.
  • Safety: The test system is characterized by a high sensitivity and specificity and the assay is monitored by an internal extraction and amplification control. Thus reliable results are guaranteed.
  • Differentiation of HSV-1 and HSV-2: Because of the significantly greater virulence of HSV-2, the determination of virus subtype provides additional prognostic information about the recurrence risk, frequency of viral shedding and risk of transmission.
  • User-friendly: The combination of an automated nucleic acid extraction with subsequent detection in the FluoroCycler® saves valuable time and enables optimal integration into your lab.
  • CE-marked: No need for elaborate validation studies.

At a glance
Molecular genetic test system for differentiation of HSV-1 and HSV-2

Starting material:
Swab and cerebrospinal fluid

DNA extraction:
GXT NA Extraction Kit (with GenoXtract®)

Instrument for amplification and detection:
FluoroCycler® 12

Order number:
24 Tests No. 61224
96 Tests No. 61296
96 Tests No. 61296A (including GXT NA Extraction Kit )
Proteinase K Set No. 405002
SW Set No. 270

Technology:
FluoroType® technology

Downloads:
Instruction for Use (IFU)
Flyer

Information request:
Enquiry