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DNA•STRIP®-technology

Your technology with high sensitivity and maximum specificity. DNA or RNA is isolated from the specimen, amplified, and detected via a hybridization and alkaline phosphatase reaction on a membrane strip.

Following DNA isolation, nucleic acids are selectively replicated in an amplification reaction. In the next step, the amplicons are chemically denatured, since detection on the DNA•STRIP® is done using single-stranded DNA. .

HybridizationThe DNA•STRIP® is coated with highly specific probes which are complementary to selectively amplified nucleic acid sequences.  The single-stranded amplicon binds specifically to the analog probes during hybridization, while non-specifically bound amplicons are removed in subsequent washing steps.

Conjugate bindingDuring the conjugate reaction, the specifically bound amplicon is marked with the enzyme alkaline phosphatase and is then made visible in a colorimetric detection reaction.
 
Color formation In this way, a specific banding pattern develops on the DNA•STRIP®. Using a test-specific evaluation template, the test result can be read out quickly and clearly. Using this assay you can reliably determine the genotype or microbiological pathogen present as well as its resistances.

 

Your benefits with the DNA•STRIP®-technology

  • Definite result: internal controls document the validity of the results and ensure accurate test execution.
  • Low implementation costs: the technology does not require any costly equipment. Even small production runs can be efficiently processed at low costs.
  • Can be automated for larger production runs: detection on the DNA•STRIP® can be done manually as well as automatically. This allows optimal integration into laboratories routines of any size.
  • Efficient processing: all DNA•STRIP® technology test systems can be combined with each other during processing.  This permits joint execution of several human-genetic and microbiological parameters and therefore offers you efficient routine diagnostic testing.
    Technic-brochure DNA•STRIP® technology

Test systems 

GenoType MRSA Direct
Geno
Type Staphylococcus
Geno
Type MRSA
Geno
Type Mycobacteria Direct
Geno
Type MTBC
Geno
Type Mycobacterium CM
Geno
Type Mycobacterium AS
Geno
Type MTBDRplus
Geno
Type MTBDRsl
Geno
Type LepraeDR
Geno
Type HelicoDR
Geno
Type CDiff
Geno
Type EHEC
Geno
Type Enterococcus
Geno
Type Bac-IDent
Geno
Type BC grampositive
Geno
Type BC gramnegative
micro-
IDent®
micro-IDent®plus11

GenoType CVD
Thrombo
Type®
ThromboType®plus
GenoType MTHFR
Geno
Type PAI-1
Geno
Type ApoE
GenoType HH
GenoType AAT
Geno
Type LCT
Geno
Type SugarTol